Feng C G, Palendira U, Demangel C, Spratt J M, Malin A S, Britton W J
Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales 2042, Australia.
Infect Immun. 2001 Jun;69(6):4174-6. doi: 10.1128/IAI.69.6.4174-4176.2001.
Sequential immunization with mycobacterial antigen Ag85B-expressing DNA and Mycobacterium bovis bacille Calmette-Guerin (BCG) was more effective than BCG immunization in protecting against Mycobacterium tuberculosis infection. Depletion of the CD8(+) T cells in the immunized mice impaired protection in their spleens, indicating that this improved efficacy was partially mediated by CD8(+) T cells.
用表达分枝杆菌抗原Ag85B的DNA和牛分枝杆菌卡介苗(BCG)进行序贯免疫在预防结核分枝杆菌感染方面比BCG免疫更有效。免疫小鼠中CD8(+) T细胞的耗竭损害了其脾脏中的保护作用,表明这种提高的疗效部分是由CD8(+) T细胞介导的。