Fushimi K, Marumo F
Second Department of Internal Medicine, School of Medicine, Tokyo Medical and Dental University, Japan.
Curr Opin Nephrol Hypertens. 1995 Sep;4(5):392-7. doi: 10.1097/00041552-199509000-00003.
The aquaporin water channels are expressed in various fluid-transporting epithelia. Physiological and genetic investigations have revealed that aquaporin channel-like intrinsic protein is expressed in numerous tissues, but its significance in water transport physiology is unclear. It has been shown that aquaporin-collecting duct is a vasopressin-responsive water channel, and that it is regulated by a membrane shuttle mechanism. Three unique models for a water pore have been presented but further studies will be required to verify them. New aquaporin members have been isolated and their discrete localization may reflect their specific physiological roles.
水通道蛋白水通道在各种液体运输上皮细胞中表达。生理学和遗传学研究表明，水通道蛋白样内在蛋白在许多组织中表达，但其在水运输生理学中的意义尚不清楚。已经表明，集合管水通道蛋白是一种抗利尿激素反应性水通道，并且它受膜穿梭机制调节。已经提出了三种独特的水孔模型，但需要进一步研究来验证它们。新的水通道蛋白成员已被分离出来，它们的离散定位可能反映了它们特定的生理作用。
