Hoffman B B, Ziyadeh F N
Penn Center for Molecular Studies of Kidney Diseases, University of Pennsylvania School of Medicine, Philadelphia, USA.
Curr Opin Nephrol Hypertens. 1995 Sep;4(5):406-11. doi: 10.1097/00041552-199509000-00006.
Cloning studies have characterized a large gene family of facilitative glucose transporters that are expressed in a tissue-specific manner, and at least two sodium-glucose co-transporters in brush-border membranes of intestinal and renal epithelia. These different transporters play specific roles in glucose transport and homeostasis because of their different tissue distribution, kinetic properties, and regulation of function. This review discusses recent advances in the study of glucose transporters and the regulation of their expression in the normal kidney and in diabetes.
克隆研究已鉴定出一个以组织特异性方式表达的易化性葡萄糖转运蛋白的大基因家族，以及肠道和肾上皮细胞刷状缘膜中的至少两种钠-葡萄糖共转运蛋白。由于这些不同转运蛋白的组织分布、动力学特性和功能调节不同，它们在葡萄糖转运和体内平衡中发挥着特定作用。本文综述了葡萄糖转运蛋白及其在正常肾脏和糖尿病中表达调控研究的最新进展。
