Gould G W, Bell G I
Department of Biochemistry, University of Glasgow, UK.
Trends Biochem Sci. 1990 Jan;15(1):18-23. doi: 10.1016/0968-0004(90)90125-u.
The uptake of glucose into most eukaryotic cells is accomplished by a carrier-mediated transport system, facilitative diffusion, which transports glucose down its chemical gradient in a stereospecific manner. Recent studies have shown that facilitative transport of glucose across the plasma membrane is mediated by a family of structurally related proteins. This review summarizes the structural and functional features of the family of facilitative glucose transporters.
大多数真核细胞摄取葡萄糖是通过一种载体介导的转运系统——易化扩散来完成的，该系统以立体特异性方式顺着葡萄糖的化学梯度转运葡萄糖。最近的研究表明，葡萄糖跨质膜的易化转运是由一族结构相关的蛋白质介导的。本综述总结了易化葡萄糖转运蛋白家族的结构和功能特征。
