Antico A
Ann Allergy Asthma Immunol. 1996 Jan;76(1):37-40. doi: 10.1016/S1081-1206(10)63404-7.
Oral allergy syndrome is a distinctive type of allergy to food resulting from direct contact between food and the oral mucosa. Normally, it affects patients who are allergic to pollens. It can be challenged by testing for hypersensitivity to fresh fruit or vegetables in well-known associations. Oral allergy syndrome rarely occurs in patients with other types of allergies, or to food not associated with pollens. Only occasionally does chestnut cause hypersensitivity. There are only a few reported cases, depending on cross-reactivity in previously latex-hypersensitive patients. Oral allergy syndrome to chestnut in a patient with respiratory allergy to Dermatophagoides is therefore unusual and worth reporting.
To describe the clinical features and their differences from previously reported cases and to analyze the techniques and methodologic problems related to in vivo and in vitro diagnosis.
Case report. Skin tests with commercial and freshly made extracts and by the prick-by-prick method. Challenge test. Specific IgE antibody assay. Prausnitz-Küstner reaction.
The challenge with fresh food confirmed an oral allergy syndrome to chestnut. Clear symptoms of rhinoconjunctivitis and asthma set in as well. Skin tests with several commercial extracts and the prick-by-prick test were negative and so was specific IgE assay in serum by RAST and other immunoenzymatic methods. Skin prick test with a freshly prepared extract of fresh chestnut and the passive transfer reaction were positive.
The case of oral allergy syndrome to chestnut reported here appears to be a manifestation of immediate IgE-dependent hypersensitivity.
口腔过敏综合征是一种因食物与口腔黏膜直接接触而引发的独特食物过敏类型。通常，它会影响对花粉过敏的患者。在一些知名的关联中，通过对新鲜水果或蔬菜的过敏测试可以对其进行验证。口腔过敏综合征很少发生在患有其他类型过敏的患者身上，或者对与花粉无关的食物过敏的患者身上。只有偶尔栗子会引发过敏反应。根据先前乳胶过敏患者的交叉反应，仅有少数病例报道。因此，一名对粉尘螨有呼吸道过敏的患者出现对栗子的口腔过敏综合征是不寻常的，值得报道。
描述其临床特征以及与先前报道病例的差异，并分析与体内和体外诊断相关的技术及方法学问题。
病例报告。使用市售和新鲜制备的提取物进行皮肤试验，并采用点刺法。激发试验。特异性IgE抗体检测。普劳斯尼茨 - 屈斯特纳反应。
新鲜食物激发试验证实了对栗子的口腔过敏综合征。同时还出现了明显的鼻结膜炎和哮喘症状。使用几种市售提取物进行的皮肤试验和点刺试验均为阴性，通过放射变应原吸附试验（RAST）和其他免疫酶法检测血清中的特异性IgE也是阴性。用新鲜栗子制备的提取物进行皮肤点刺试验和被动转移反应均为阳性。
本文报道的对栗子的口腔过敏综合征病例似乎是IgE介导的速发型超敏反应的一种表现。
