内皮素可抑制兔和人睫状体中环磷酸腺苷的生成。
Endothelins inhibit cyclic AMP production in rabbit and human ciliary processes.
作者信息
Bausher L P
机构信息
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, USA.
出版信息
J Ocul Pharmacol Ther. 1995 Summer;11(2):135-43. doi: 10.1089/jop.1995.11.135.
The effects of endothelins on cyclic AMP production have been studied in rabbit and human ciliary processes. Endothelins inhibit basal, isoproterenol-, and VIP-stimulated cyclic AMP production in rabbit ciliary processes and forskolin-stimulated cyclic AMP production in rabbit and human ciliary processes. EC50s for inhibition of forskolin-stimulated cyclic AMP production using rabbit tissue were similar: ET-1, 70 nM; ET-2, 40 nM; ET-3, 70 nM; maximum inhibition was about 76% for each ligand. These data are consistent with the presence of an ETB receptor. Endothelin-like immunoreactivity in rabbit aqueous humor was measured to be 226 pg/ml.
已经在兔和人睫状体中研究了内皮素对环磷酸腺苷（cAMP）生成的影响。内皮素抑制兔睫状体中的基础、异丙肾上腺素和血管活性肠肽（VIP）刺激的cAMP生成，以及兔和人睫状体中福斯可林刺激的cAMP生成。使用兔组织抑制福斯可林刺激的cAMP生成的半数有效浓度（EC50）相似：内皮素-1（ET-1）为70 nM；内皮素-2（ET-2）为40 nM；内皮素-3（ET-3）为70 nM；每种配体的最大抑制率约为76%。这些数据与ETB受体的存在一致。测得兔房水中内皮素样免疫反应性为226 pg/ml。
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