成年人类睫状体中环磷酸腺苷生成的调节

Regulation of cyclic AMP production in adult human ciliary processes.

作者信息

Bausher L P, Horio B

机构信息

Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT, USA.

出版信息

Exp Eye Res. 1995 Jan;60(1):43-8. doi: 10.1016/s0014-4835(05)80082-x.

DOI:10.1016/s0014-4835(05)80082-x

PMID:7720804

Abstract

Cyclic AMP production in intact ciliary processes from elderly human donors is subject to stimulatory and inhibitory control by various agents. Stimulation of cAMP production is observed with forskolin, vasoactive intestinal peptide, or the beta-adrenergic agonist isoproterenol. Inhibition of forskolin-stimulated cAMP production is observed with endothelin-2 or PAC. The inhibitory effect of PAC is blocked by the specific alpha 2-adrenergic antagonist, yohimbine. Endothelin-2 has no effect on basal cAMP production. These data document the positive and negative regulation of cAMP responses in adult human ciliary processes and support the idea that cAMP is a key intermediate in the regulation of aqueous humor formation.

摘要

来自老年人类供体的完整睫状体中，环磷酸腺苷（cAMP）的产生受到多种因子的刺激和抑制性调控。用毛喉素、血管活性肠肽或β-肾上腺素能激动剂异丙肾上腺素可观察到cAMP产生的刺激作用。用内皮素-2或PAC可观察到对毛喉素刺激的cAMP产生的抑制作用。PAC的抑制作用可被特异性α2-肾上腺素能拮抗剂育亨宾阻断。内皮素-2对基础cAMP产生无影响。这些数据证明了成年人类睫状体中cAMP反应的正负调控，并支持cAMP是房水形成调节中的关键中间产物这一观点。