Bardon S, Le M T, Alessandri J M
Institut National de la Recherche Agronomique, Laboratoire de Nutrition et Sécurité Alimentaire, Jouy-en-Josas, France.
Cancer Lett. 1996 Jan 19;99(1):51-8. doi: 10.1016/0304-3835(95)04037-4.
The incorporation and conversion of polyunsaturated fatty acids (PUFA) of n-3 and n-6 families were examined in the T47D breast cancer cell line in parallel with their effects on cell proliferation. In low serum-containing medium, PUFA exerted differential growth effects, depending both on their affiliation and unsaturation degree. The study of PUFA processing suggested that T47D cells are deficient in delta 6 and delta 4-desaturation activities whereas they can process to delta 5-desaturation. Thus, the PUFA growth effect on T47D cells appeared to be associated with a lack of desaturation.
在T47D乳腺癌细胞系中，研究了n-3和n-6家族多不饱和脂肪酸（PUFA）的掺入和转化情况，并同时考察了它们对细胞增殖的影响。在低血清培养基中，PUFA根据其所属类别和不饱和度发挥不同的生长效应。对PUFA代谢过程的研究表明，T47D细胞缺乏δ6和δ4去饱和活性，但能够进行δ5去饱和。因此，PUFA对T47D细胞的生长效应似乎与缺乏去饱和作用有关。
