针对乳腺癌中的铁死亡
Targeting ferroptosis in breast cancer.
作者信息
Li Zhaoqing, Chen Lini, Chen Cong, Zhou Yulu, Hu Dengdi, Yang Jingjing, Chen Yongxia, Zhuo Wenying, Mao Misha, Zhang Xun, Xu Ling, Wang Linbo, Zhou Jichun
机构信息
Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, 310000, Zhejiang, China.
Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), 2nd Affiliated Hospital, School of Medicine, Zhejiang University, 310009, Hangzhou, Zhejiang, China.
出版信息
Biomark Res. 2020 Nov 5;8(1):58. doi: 10.1186/s40364-020-00230-3.
Ferroptosis is a recently discovered distinct type of regulated cell death caused by the accumulation of lipid-based ROS. Metabolism and expression of specific genes affect the occurrence of ferroptosis, making it a promising therapeutic target to manage cancer. Here, we describe the current status of ferroptosis studies in breast cancer and trace the key regulators of ferroptosis back to previous studies. We also compare ferroptosis to common regulated cell death patterns and discuss the sensitivity to ferroptosis in different subtypes of breast cancer. We propose that viewing ferroptosis-related studies from a historical angle will accelerate the development of ferroptosis-based biomarkers and therapeutic strategies in breast cancer.
铁死亡是最近发现的一种由脂质活性氧积累引起的独特的程序性细胞死亡类型。特定基因的代谢和表达会影响铁死亡的发生，使其成为治疗癌症的一个有前景的靶点。在此，我们描述了乳腺癌中铁死亡研究的现状，并将铁死亡的关键调节因子追溯至以往的研究。我们还将铁死亡与常见的程序性细胞死亡模式进行比较，并讨论乳腺癌不同亚型对铁死亡的敏感性。我们认为，从历史角度审视与铁死亡相关的研究将加速基于铁死亡的生物标志物和治疗策略在乳腺癌中的发展。
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