Mendicute J, Ondarra A, Eder F, Ostolaza J I, Salaberria M, Lamsfus J M
Department of Ophthalmology, Hospital de Gipuzkoa, San Sebastian, Spain.
CLAO J. 1995 Oct;21(4):252-5.
We treated three patients with Aspergillus keratomycosis with collagen shields soaked in amphotericin B (0.50%) for 2 hours at 25 degrees C before application. These shields, replaced daily, were used in conjunction with amphotericin B (0.25%) eye drops, which were applied every 2 hours. Cultures from the eyes of all patients became negative within 15 days of treatment. Subsequently, two patients required keratoplasty. The results suggest that collagen shields prepared this way deliver an adequate concentration of amphotericin B to the cornea, aid its tolerance, and improve the prognosis of Aspergillus keratomycosis. Further studies are needed to define the minimum therapeutic concentrations necessary to inhibit the growth of the fungus and to avoid a toxic effect on the cornea.
我们对三名曲霉菌性角膜溃疡患者进行了治疗，所用的胶原盾在25摄氏度下用两性霉素B（0.50%）浸泡2小时后应用。这些胶原盾每天更换，同时使用两性霉素B（0.25%）滴眼液，每2小时滴眼一次。所有患者眼部培养物在治疗15天内均转为阴性。随后，两名患者需要进行角膜移植术。结果表明，以这种方式制备的胶原盾能将足够浓度的两性霉素B输送至角膜，有助于角膜耐受该药物，并改善曲霉菌性角膜溃疡的预后。需要进一步研究来确定抑制真菌生长所需的最低治疗浓度，并避免对角膜产生毒性作用。
