Itoi M, Kim O, Kimura T, Kanai A, Momose T, Kanki K, Yamaguchi T, Ueno Y, Kurokawa M, Komemushi S
Department of Ophthalmology, Juntendo University School of Medicine, Chiba, Japan.
CLAO J. 1995 Oct;21(4):261-4.
We evaluated the efficacy of sodium hyaluronate ophthalmic solutions on 3 and 9 o'clock staining with rigid contact lens wearers in a double masked multicenter study involving four institutions and 43 patients. Both sodium hyaluronate (0.1%) and control ophthalmic solutions (artificial tears) without preservative were used. Patients were randomly divided into two groups. The test group received sodium hyaluronate ophthalmic solution, and the control group received artificial tears as a control ophthalmic solution. The agents were instilled six times per day for 2 weeks while patients wore contact lenses. Although subjective symptoms improved similarly in the two groups, slit lamp observation, corneal staining, and anterior segment photography demonstrated improved results in eyes having received sodium hyaluronate ophthalmic solutions. We conclude that sodium hyaluronate ophthalmic solution is effective and safe for treating 3 and 9 o'clock staining in rigid contact lens wearers.
在一项涉及四个机构和43名患者的双盲多中心研究中，我们评估了透明质酸钠眼药水对硬性隐形眼镜佩戴者3点和9点染色的疗效。使用了透明质酸钠（0.1%）和不含防腐剂的对照眼药水（人工泪液）。患者被随机分为两组。试验组接受透明质酸钠眼药水，对照组接受人工泪液作为对照眼药水。在患者佩戴隐形眼镜期间，每天滴注药物6次，持续2周。尽管两组的主观症状改善情况相似，但裂隙灯观察、角膜染色和眼前节摄影显示，接受透明质酸钠眼药水的眼睛有更好的结果。我们得出结论，透明质酸钠眼药水对治疗硬性隐形眼镜佩戴者的3点和9点染色是有效且安全的。
