Boffa M J, Wilkinson S M, Beck M H
Skin Hospital, University of Manchester School of Medicine, UK.
Contact Dermatitis. 1995 Sep;33(3):149-51. doi: 10.1111/j.1600-0536.1995.tb00535.x.
To evaluate which corticosteroids are most useful for the detection of corticosteroid contact allergy in our population, 2123 patients were patch tested with a series of 6 corticosteroids, in parallel with a standard series, and other relevant investigations. 127 patients (5.98%) were allergic to one or more corticosteroids; 96 to tixocortol pivalate, 51 to hydrocortisone butyrate, 47 to budesonide, 11 to betamethasone valerate, 11 to clobetasone butyrate and 8 to clobetasol propionate. 511 patients with negative patch tests to the limited corticosteroid series were in addition tested to a further 12 corticosteroids; only 1 of these patients reacted to a corticosteroid. A combination of tixocortol pivalate and budesonide thus detected 91.3% of corticosteroid-allergic subjects. We believe that both these allergens should be included in the standard series and that there may be a case for extending this further.
为评估哪种皮质类固醇对检测我们人群中的皮质类固醇接触性过敏最为有用，对2123例患者进行了一系列6种皮质类固醇的斑贴试验，同时进行标准系列试验及其他相关检查。127例患者（5.98%）对一种或多种皮质类固醇过敏；96例对匹伐酸替可的松过敏，51例对丁酸氢化可的松过敏，47例对布地奈德过敏，11例对戊酸倍他米松过敏，11例对丁酸氯倍他松过敏，8例对丙酸氯倍他索过敏。511例对有限皮质类固醇系列斑贴试验阴性的患者还接受了另外12种皮质类固醇的检测；这些患者中只有1例对皮质类固醇有反应。因此，匹伐酸替可的松和布地奈德的组合检测出了91.3%的皮质类固醇过敏受试者。我们认为这两种变应原都应纳入标准系列，并且可能有进一步扩展的理由。
