斑秃治疗后对皮损内注射曲安奈德的迟发型超敏反应。皮内试验。
Delayed hypersensitivity reaction to intralesional triamcinolone acetonide following treatment for alopecia areata. Intradermal testing.
作者信息
Kreeshan Firas Constantin, Hampton Philip
机构信息
Department of Dermatology, Royal Victoria Infirmary, Newcastle Upon Tyne, United Kingdom.
出版信息
J Dermatol Case Rep. 2015 Dec 31;9(4):107-9. doi: 10.3315/jdcr.2015.1216.
BACKGROUND
Hypersensitivity reactions to intralesional corticosteroids are very rare and have been infrequently reported. Patch testing is considered the gold standard for diagnosing contact allergic dermatitis. However, intradermal testing is thought to be more accurate and sensitive in selected cases.
MAIN OBSERVATION
We describe a case of a delayed hypersensitivity reaction to intralesional triamcinolone acetonide following the treatment of alopecia areata. Patch testing to triamcinolone was negative but intradermal testing with a small volume of the same reagent elicited a strong reaction.
CONCLUSIONS
Patch testingmay be unsuccessful in detecting delayed reactions to intralesional corticosteroids. In such cases intradermal testing at a non-cosmetically sensitive sitemay be a useful diagnostic tool.
背景
对皮损内注射皮质类固醇的超敏反应非常罕见，鲜有报道。斑贴试验被认为是诊断接触性过敏性皮炎的金标准。然而，在某些特定情况下，皮内试验被认为更准确、更敏感。
主要观察结果
我们描述了1例斑秃患者在接受皮损内注射曲安奈德后发生迟发型超敏反应的病例。对曲安奈德进行斑贴试验结果为阴性，但用少量相同试剂进行皮内试验引发了强烈反应。
结论
斑贴试验可能无法检测到对皮损内注射皮质类固醇的迟发型反应。在这种情况下，在非美容敏感部位进行皮内试验可能是一种有用的诊断工具。
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