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A reassessment of Y chromosomal behaviour in germ cells and Sertoli cells of the mouse as revealed by in situ hybridisation.

作者信息

Chandley A C, Speed R M

机构信息

MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK.

出版信息

Chromosoma. 1995 Dec;104(4):282-6. doi: 10.1007/BF00352259.

DOI:10.1007/BF00352259
PMID:8565704
Abstract

In situ hybridisation experiments were carried out to reappraise the state of condensation of the Y chromosome in germ cells and Sertoli cells of the mouse. Previous work had suggested that all testicular cells showed a condensed Y chromosome prior to the adult stage. We now demonstrate that, although the Y chromosome is condensed in pre-pubertal Sertoli cells, it is greatly expanded in primordial germ cells (gonocytes). An expanded Y-signal is first seen in Sertoli cell nuclei at or around day 21 of postnatal development, coinciding with the first appearance of spermatids in the germinal epithelium.

摘要

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本文引用的文献

1
AN AIR-DRYING METHOD FOR MEIOTIC PREPARATIONS FROM MAMMALIAN TESTES.一种用于制备哺乳动物睾丸减数分裂标本的空气干燥法。
Cytogenetics. 1964;3:289-94. doi: 10.1159/000129818.
2
Duration of spermatogenesis in the mouse and timing of stages of the cycle of the seminiferous epithelium.小鼠精子发生的持续时间及生精上皮周期各阶段的时间安排。
Am J Anat. 1956 Nov;99(3):507-16. doi: 10.1002/aja.1000990307.
3
Chromatin condensation behaviour of the Y chromosome in the human testis. I. Evidence for decondensation of distal Yq in germ cells prior to puberty with a switch to Sertoli cells in adults.
人类睾丸中Y染色体的染色质凝聚行为。I.青春期前生殖细胞中Yq远端去凝聚的证据以及成年后向支持细胞转变的情况。
Chromosoma. 1993 Jun;102(6):421-7. doi: 10.1007/BF00360407.
4
Organization of the Y chromosome in testis cells of fetal, subadult and adult mice as determined by in situ hybridization.
Chromosoma. 1993 Nov;102(9):618-22. doi: 10.1007/BF00352309.
5
A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis.一个具有RNA结合蛋白同源性的Y染色体基因家族：控制人类精子发生的无精子症因子AZF的候选基因。
Cell. 1993 Dec 31;75(7):1287-95. doi: 10.1016/0092-8674(93)90616-x.
6
Y353/B: a candidate multiple-copy spermiogenesis gene on the mouse Y chromosome.Y353/B：小鼠Y染色体上一个潜在的多拷贝精子发生基因。
Mamm Genome. 1994 Apr;5(4):203-10. doi: 10.1007/BF00360546.
7
A comparison between the morphology and cell kinetics of gonocytes and adult type undifferentiated spermatogonia in the mouse.小鼠生殖母细胞与成年型未分化精原细胞的形态学和细胞动力学比较。
Int J Androl. 1981 Aug;4(4):475-93. doi: 10.1111/j.1365-2605.1981.tb00732.x.
8
Morphological and temporal sequence of meiotic prophase development at puberty in the male mouse.雄性小鼠青春期减数分裂前期发育的形态学和时间序列
J Cell Sci. 1984 Jan;65:249-63. doi: 10.1242/jcs.65.1.249.
9
Sex-reversed mice: XX and XO males.性反转小鼠：XX和XO雄性小鼠。
Cytogenetics. 1971;10(5):318-37. doi: 10.1159/000130151.
10
Molecular cloning and sequence analysis of a mouse Y chromosome RNA transcript expressed in the testis.在睾丸中表达的小鼠Y染色体RNA转录本的分子克隆与序列分析。
Nucleic Acids Res. 1987 Apr 10;15(7):2959-69. doi: 10.1093/nar/15.7.2959.