Ientile R, Malecka B, Picciurro V, Naso A, Pedale S, Macaione S
Institute of Biochemical Sciences and Clinical Biochemistry, Faculty of Medicine, University of Messina, Italy.
FEBS Lett. 1996 Jan 22;379(1):82-4. doi: 10.1016/0014-5793(95)01490-x.
High levels of nitric oxide synthase were found in the early stages of developing chick embryo retina. The enzyme activity sharply decreased up to 13-day-old chick embryo retina, when the level of the last embryonic day was reached. The results show that nitric oxide is synthesized in chick embryo retina prior to synaptogenesis. The incubation of chick embryo retinas in presence of NMDA increased the synthesis of nitric oxide, thus, the appearance of nitric oxide production before the synaptogenesis in the retina as well as in the brain may be considered as signal for the development and shaping of neuronal and non-neuronal cells.
在发育中的鸡胚视网膜早期发现了高水平的一氧化氮合酶。在达到胚胎最后一天水平时，该酶活性在13日龄鸡胚视网膜中急剧下降。结果表明，一氧化氮在突触形成之前就在鸡胚视网膜中合成。在NMDA存在的情况下孵育鸡胚视网膜会增加一氧化氮的合成，因此，视网膜以及大脑中突触形成之前一氧化氮产生的出现可能被视为神经元和非神经元细胞发育和塑形的信号。
