Obraztsov N V, Shimanovskiĭ N L
Farmakol Toksikol. 1977 Mar-Apr;40(2):184-7.
The effect of roentgen-contrast media on the hemolytic resistance of erythrocytes in conditions of a "hypotonic shock" and on the peroxidation of the erythrocytes lipids membranes was studied. It is shown that all the contrast media potentiate the erythrocytes hemolysis, but do not affect the rate of the lipids peroxidation. Preliminary introduction of pipolphen in a therapeutic dose in a erythrocytes suspension increases the resistance of membranes to the action of the roentgen-contrast media.
研究了X射线造影剂在“低渗休克”条件下对红细胞溶血抵抗力以及对红细胞脂质膜过氧化作用的影响。结果表明,所有造影剂均能增强红细胞溶血,但不影响脂质过氧化速率。预先在红细胞悬液中以治疗剂量引入异丙嗪可增加膜对X射线造影剂作用的抵抗力。