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锌离子对人红细胞某些体外渗透特性的影响(作者译)

[Effect of zinc ions on the selected osmotic characteristics of human erythrocytes in vitro (author's transl)].

作者信息

Kabat I A, Niedworok J, Błaszczyk J

出版信息

Zentralbl Bakteriol Orig B. 1978 May;166(4-5):375-80.

PMID:654691
Abstract

Effect of zinc on the osmotic fragility-stability of human erythrocytes in hypotonic NaCl solutions and on the reversion of hemolysis was studied in vitro. Erythrocytes washed in 0.9% NaCl were incubated in 1.5 X 10(-3) M ZnSO4 solution in 0.6% NaCl. The obtained results indicate an osmotic stabilization of the erythrocyte membrane by Zn2+ ions increase in osmotic fragility-stability in hypotonic NaCl solutions and increase in reversion of hemolysis due to the effect of Zn2+ ions. As the process of stabilization of the erythrocyte membrane by zinc ions was found to be independent of temperature, a non-enzymatic character of this phenomenon is postulated on this basis and on the basis of literature data.

摘要

体外研究了锌对人红细胞在低渗氯化钠溶液中的渗透脆性-稳定性以及溶血逆转的影响。用0.9%氯化钠洗涤的红细胞在含0.6%氯化钠的1.5×10⁻³M硫酸锌溶液中孵育。所得结果表明,Zn²⁺离子可使红细胞膜发生渗透稳定作用,在低渗氯化钠溶液中渗透脆性-稳定性增加,且由于Zn²⁺离子的作用溶血逆转增加。由于发现锌离子对红细胞膜的稳定过程与温度无关,基于此并根据文献数据推测该现象具有非酶促特性。

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