Bushma M I, Lukienko P I
Farmakol Toksikol. 1977 Mar-Apr;40(2):200-2.
It was established that with intraperitoneal introduction of uridine and cytidine their DL50 for mice equals 5100 and 2700 mg/kg, respectively. In doses of 1/27 and 1/50 of DL50 cytidine reduces by 50 per cent the edema of the rat's paw in a dextran-and formaldehyde-induced inflammation, brings down the body temperature by 1.0--1.2 degrees and cuts down the death-rate among the animals in hyperthermia produced by 2,4-dinitrophenol. Uridine does not affect significantly the course of aseptic inflammation. In adrenalectomized rats the antiexudative action of cytidine does not manifest itself. Both nuclesides fail to exercise any significant influence on the cardiac activity and respiration in cats.
已确定，通过腹腔注射给予尿苷和胞苷时，它们对小鼠的半数致死量分别为5100和2700毫克/千克。在半数致死量的1/27和1/50剂量下，胞苷可使右旋糖酐和甲醛诱导的大鼠爪部炎症水肿减轻50%，使体温降低1.0 - 1.2摄氏度，并降低2,4 - 二硝基苯酚引起的动物热疗死亡率。尿苷对无菌性炎症过程无显著影响。在肾上腺切除的大鼠中，胞苷的抗渗出作用未表现出来。两种核苷对猫的心脏活动和呼吸均无显著影响。
