[Pharmacology of uridine and cytidine].

It was established that with intraperitoneal introduction of uridine and cytidine their DL50 for mice equals 5100 and 2700 mg/kg, respectively. In doses of 1/27 and 1/50 of DL50 cytidine reduces by 50 per cent the edema of the rat's paw in a dextran-and formaldehyde-induced inflammation, brings down the body temperature by 1.0--1.2 degrees and cuts down the death-rate among the animals in hyperthermia produced by 2,4-dinitrophenol. Uridine does not affect significantly the course of aseptic inflammation. In adrenalectomized rats the antiexudative action of cytidine does not manifest itself. Both nuclesides fail to exercise any significant influence on the cardiac activity and respiration in cats.