Spitz I M, Rosen E, Ben-Aderet N, Polishuk W, Jaffe H, Bercovici B
Fertil Steril. 1977 May;28(5):535-40.
Six patients with all of the clinical and laboratory characteristics of isolated hypogonadotropic hypogonadism (bihormonal gonadotropin deficiency) were treated with human menopausal gonadotropins (hMG, Pergonal) and human chorionic gonadotropin (hCG). Of a total of 37 courses of treatment administered, there was evidence of ovulation in 32 (29%). The first four subjects had a total of six pregnancies in 13 treatment cycles. In the remaining two subjects, there were abnormalities in the seminal fluid of both husbands and, as a consequence, only one patient conceived. The average dose and duration of hMG therapy was 3310 IU (44 ampules), administered for 13 days. A wide range of hCG dosage was used to induce ovulation, but three subjects conceived following 5000 IU of hCG on 2 successive days. None of our subjects developed any evidence of the hyperstimulation syndrome, and there was only one instance of twin birth. Serial determinations of hLH performed during hMG therapy were lower than those noted during the normal follicular phase. In contrast, hFSH levels were in the normal follicular phase range. the high success rate in these subjects indicates that the prognosis for inducing ovulation in patients with hypogonadotropic hypogonadism is good.
六名具有孤立性促性腺激素缺乏症（双激素促性腺激素缺乏）所有临床和实验室特征的患者接受了人绝经期促性腺激素（hMG， Pergonal）和人绒毛膜促性腺激素（hCG）治疗。在总共进行的37个疗程治疗中，有32个疗程（29%）出现排卵迹象。前四名受试者在13个治疗周期中共怀孕6次。在其余两名受试者中，两名丈夫的精液均有异常，因此只有一名患者受孕。hMG治疗的平均剂量和持续时间为3310国际单位（44安瓿），给药13天。诱导排卵使用了广泛的hCG剂量范围，但三名受试者在连续两天注射5000国际单位hCG后受孕。我们的受试者均未出现任何卵巢过度刺激综合征的迹象，且仅有一例双胞胎出生。在hMG治疗期间进行的hLH系列测定低于正常卵泡期的测定值。相比之下，hFSH水平处于正常卵泡期范围内。这些受试者的高成功率表明，促性腺激素缺乏症患者诱导排卵的预后良好。
