Ilesanmi A O, Adeleye J A, Osotimehin B O
Department of Obstetrics and Gynecology, University College Hospital, Ibadan, Nigeria.
Afr J Med Med Sci. 1995 Mar;24(1):97-101.
Infertility remains a medico-social problem in Nigeria and it accounts for a large percentage of outpatient gynecological consultations. The evaluation of the infertile couple remains a continuing challenge to the practising doctor in this part of the world. The need to evaluate the two methods commonly used for determining ovulation in these patients is indicated. Endometrial biopsy specimen and a single sample for serum progesterone estimation were obtained simultaneously in the luteal phase from 50 normally menstruating infertile Nigerian women. Subsequent analysis showed that a serum progesterone value of 6.6 nmol/l (2.2 ng/ml) or above was always associated with a secretory endometrium. Forty-six cycles yielded sufficient information to compare the two methods for confirmation of ovulation. Patients who ovulated with a progesterone value of 6.6 nmol/l (2.2 ng/ml) were 91.3% (42/46) or above, while 89% (41/46) showed secretory endometrium. Forty-six of the cases 86.9% (40/46) were judged to have ovulated by both parameters while 6.5% demonstrated anovulatory cycle using both criteria. From the study, a significant correlation was obtained between endometrial biopsy and progesterone assay methods in confirming ovulation.
在尼日利亚，不孕症仍然是一个医学社会问题，在门诊妇科咨询中占很大比例。对不孕夫妇进行评估，对世界上这个地区的执业医生来说仍然是一项持续的挑战。有必要对这些患者中常用的两种排卵测定方法进行评估。在黄体期，从50名月经正常的尼日利亚不孕妇女中同时获取子宫内膜活检标本和一份血清孕酮测定样本。后续分析表明，血清孕酮值6.6 nmol/l（2.2 ng/ml）及以上总是与分泌期子宫内膜相关。46个周期产生了足够的信息来比较这两种排卵确认方法。孕酮值6.6 nmol/l（2.2 ng/ml）及以上时排卵的患者占91.3%（42/46），而89%（41/46）显示为分泌期子宫内膜。46例中的40例（86.9%）通过这两个参数判断为排卵，而6.5%的病例使用这两个标准均显示为无排卵周期。从该研究中，在确认排卵方面，子宫内膜活检和孕酮测定方法之间存在显著相关性。
