Scommegna A, Ilekis J, Sotrel G, Auletta F J
Fertil Steril. 1977 May;28(5):581-6. doi: 10.1016/s0015-0282(16)42561-6.
The effect on rabbit endometrial prostaglandin F caused by progesterone delivered directly to the uterus was investigated. Four groups of animals were used in the experiment: (1) no treatment (control); (2) an empty Silastic capsule (as an intrauterine device [IUD]) was inserted in one horn and the other horn was sham-operated; (3) a Silastic capsule releasing 150 microng of progesterone/day was placed in one horn and the other horn was sham-operated; (4) a Silastic capsule releasing progesterone was placed in one horn and the opposite horn received an empty Silastic capsule. In group 1, which received no treatment, no difference was noted. In group 2, the prostaglandin content of the horn containing an empty IUD was significantly higher than that of the sham-operated horn. In group 3, the same significant difference was noted between the prostaglandin content of the IUD-containing, progesterone-treated horn and the sham-operated horn. In group 4, no significant difference was observed between the horn containing an inert IUD and that containing a progesterone-releasing device. The addition of progesterone to an IUD does not significantly affect the elevated prostaglandin content of the endometrium caused by an inert IUD.
研究了直接将孕酮输送到子宫对兔子宫内膜前列腺素F的影响。实验使用了四组动物：（1）不治疗（对照组）；（2）在一个子宫角插入一个空的硅橡胶胶囊（作为宫内节育器[IUD]），另一个子宫角进行假手术；（3）在一个子宫角放置一个每天释放150微克孕酮的硅橡胶胶囊，另一个子宫角进行假手术；（4）在一个子宫角放置一个释放孕酮的硅橡胶胶囊，相对的子宫角放置一个空的硅橡胶胶囊。在未接受治疗的第1组中，未观察到差异。在第2组中，含有空IUD的子宫角的前列腺素含量显著高于假手术的子宫角。在第3组中，含有IUD且接受孕酮治疗的子宫角与假手术子宫角的前列腺素含量之间也存在同样显著的差异。在第4组中，含有惰性IUD的子宫角与含有释放孕酮装置的子宫角之间未观察到显著差异。向IUD中添加孕酮不会显著影响由惰性IUD引起的子宫内膜前列腺素含量升高。
