Petrov R
Academy of Sciences of Russia, Moscow.
Allergy Proc. 1995 Jul-Aug;16(4):177-84. doi: 10.2500/108854195778666784.
Bone marrow cells of various animal species and humans produce a group of bioregulatory peptides called myelopeptides (MPs). MPs have been isolated and purified, and their physico-chemical properties have been investigated. MPs have a wide spectrum of functional activities: immunoregulatory, differentiating, and opiate-like. A new immunocorrective drug, Myelopidum, which is used effectively in clinical practice for treating diseases accompanied by immunodeficiency, has been created on the basis of MPs. Administration of Myelopidum after surgery prevents 50% to 70% of postsurgical complications, particularly postsurgery pneumonia, and also normalizes the number and balance of T-helper cells, T-suppressor cells, and B-lymphocytes in patients with chronic pulmonary diseases, resulting in a beneficial clinical effect, including a significant prolongation of remission periods. Myelopidum is also used in veterinary medicine for prophylaxis and treatment of pneumonia and enteritis in newborn and young animals. The primary structure of several myelopeptides is established. The functional activities of two, MP-1 (Phe-Leu-Gly-Phe-Pro-Thr) and MP-2 (Leu-Val-Val-Tyr-Pro-Trp), are being investigated.
各种动物物种和人类的骨髓细胞会产生一类被称为骨髓肽（MPs）的生物调节肽。骨髓肽已被分离和纯化，并且对其物理化学性质进行了研究。骨髓肽具有广泛的功能活性：免疫调节、分化以及类阿片样活性。一种新型免疫纠正药物——髓肽片，已在骨髓肽的基础上研制成功，并在临床实践中有效用于治疗伴有免疫缺陷的疾病。术后服用髓肽片可预防50%至70%的术后并发症，尤其是术后肺炎，还能使慢性肺部疾病患者的辅助性T细胞、抑制性T细胞和B淋巴细胞数量及平衡恢复正常，从而产生有益的临床效果，包括显著延长缓解期。髓肽片也用于兽医学，预防和治疗新生动物及幼龄动物的肺炎和肠炎。几种骨髓肽的一级结构已被确定。正在研究其中两种骨髓肽MP-1（苯丙氨酸-亮氨酸-甘氨酸-苯丙氨酸-脯氨酸-苏氨酸）和MP-2（亮氨酸-缬氨酸-缬氨酸-酪氨酸-脯氨酸-色氨酸）的功能活性。
