来自卷曲链霉菌的两个对卷曲霉素耐药决定簇的分析及其产物作用的表征。
Analysis of two capreomycin-resistance determinants from Streptomyces capreolus and characterization of the action of their products.
作者信息
Thiara A S, Cundliffe E
机构信息
Department of Biochemistry, University of Leicester, UK.
出版信息
Gene. 1995 Dec 29;167(1-2):121-6. doi: 10.1016/0378-1119(95)00702-4.
PMID:8566762
Abstract
Two genes encoding capreomycin (Cp)-modifying enzymes have been isolated from the producing organism Streptomyces capreolus. Cp acetyltransferase (CAC), encoded by cac, is active against all four components of the Cp complex, whereas Cp phosphotransferase (CPH), the product of cph, is active against Cp components IA and IIA (and also the related antibiotic, Vm) but not against Cp IB or Cp IIB.
摘要
从卡普霉素产生菌卷曲链霉菌中分离出了两个编码卡普霉素（Cp）修饰酶的基因。由cac基因编码的Cp乙酰转移酶（CAC）对Cp复合物的所有四个组分均有活性，而由cph基因产生的Cp磷酸转移酶（CPH）对Cp组分IA和IIA（以及相关抗生素Vm）有活性，但对Cp IB或Cp IIB没有活性。
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