Maier J A, Mariotti M, Albini A, Comi P, Prat M, Comogilio P M, Soria M R
Department of Biological and Technological Research-Dibit, San Raffaele Institute, Milan, Italy.
Int J Cancer. 1996 Jan 17;65(2):168-72. doi: 10.1002/(SICI)1097-0215(19960117)65:2<168::AID-IJC7>3.0.CO;2-X.
Kaposi's sarcoma is a highly vascularized multifocal tumor which frequently appears as a complication of HIV infection. It has been suggested that a disorder in the cytokine network may contribute to the development of the disease. We examined the expression of several cytokines in human sporadic Kaposi's-sarcoma specimens, as well as in spindle cells cultured from human lesions, and consistently found high levels of expression of hepatocyte growth factor (HGF). In addition, human lesion-derived spindle cells synthesize and secrete biologically active hepatocyte growth factor and express the hepatocyte-growth-factor receptor (c-MET). Moreover, elevated levels of transforming growth factor beta 1 (TGF beta 1) mRNA were found in lesions of human sporadic Kaposi's sarcoma and in lesion-derived spindle cells which also over-express urokinase. Since HGF, TGF beta 1 and urokinase are all involved in capillary-vessel organization, dysregulation of these interacting agents may play a role in the initiation and/or progression of Kaposi's sarcoma, stimulating the growth of spindle cells and recruiting endothelial cells into the lesion.
卡波西肉瘤是一种血管高度丰富的多灶性肿瘤，常作为HIV感染的并发症出现。有人认为细胞因子网络紊乱可能与该疾病的发生有关。我们检测了几种细胞因子在人类散发性卡波西肉瘤标本以及从人类病变中培养的纺锤状细胞中的表达情况，一致发现肝细胞生长因子（HGF）表达水平很高。此外，源自人类病变的纺锤状细胞合成并分泌具有生物活性的肝细胞生长因子，并表达肝细胞生长因子受体（c-MET）。而且，在人类散发性卡波西肉瘤病变以及也过度表达尿激酶的病变衍生纺锤状细胞中发现转化生长因子β1（TGFβ1）mRNA水平升高。由于HGF、TGFβ1和尿激酶均参与毛细血管组织的形成，这些相互作用因子的失调可能在卡波西肉瘤的起始和/或进展中起作用，刺激纺锤状细胞生长并将内皮细胞募集到病变中。
