Spatz W B, Löhle E
Unit for Morphological Brain Research, University of Freiburg, FRG.
Hear Res. 1995 Jun;86(1-2):89-99. doi: 10.1016/0378-5955(95)00059-d.
Calcium-binding proteins can act as intermediaries between changing levels of free intracellular calcium ions and the physiological response of neurons. Some of these proteins, among them calbindin (CB), calretinin (CR) and parvalbumin (PV), can act as calcium buffers. A survey of previous studies in rodents and human fetuses leads to the impression that many spiral ganglion cells co-express CB, CR, and PV. The findings of the present study suggest that, in the adult marmoset, the expression of CB is restricted to a small number of cells, most likely type II ganglion cells, and that at least some of the numerous type I ganglion cells co-express CR and PV. In the neonate marmoset, large numbers of putative type I ganglion cells from the apical cochlear turn transiently expressed a light and granular labeling for CB-like immunoreactivity, in addition to the cells we believe to be type II ganglion cells exhibiting a strong and solid CB-like staining. The spiral ganglion cells in all developmental stages co-expressed the mitochondrial enzyme cytochrome oxidase. Furthermore, a small population of CB-LI axons of unknown origin was found to terminate near the CB-immunoreactive ganglion cells.
钙结合蛋白可作为细胞内游离钙离子水平变化与神经元生理反应之间的中介。其中一些蛋白，包括钙结合蛋白（CB）、钙视网膜蛋白（CR）和小白蛋白（PV），可充当钙缓冲剂。对以往啮齿动物和人类胎儿研究的调查表明，许多螺旋神经节细胞共表达CB、CR和PV。本研究结果表明，在成年狨猴中，CB的表达仅限于少数细胞，很可能是II型神经节细胞，并且大量I型神经节细胞中至少有一些共表达CR和PV。在新生狨猴中，除了我们认为是表现出强烈而坚实的CB样染色的II型神经节细胞外，来自蜗顶的大量假定I型神经节细胞短暂表达了一种浅而颗粒状的CB样免疫反应性标记。所有发育阶段的螺旋神经节细胞都共表达线粒体酶细胞色素氧化酶。此外，发现一小群来源不明的CB-LI轴突在CB免疫反应性神经节细胞附近终止。
