顺铂给药对大鼠耳蜗内淋巴电化学组成的影响。

Effect of cisplatin administration on the electrochemical composition of endolymph in the rat cochlea.

作者信息

Laurell G, Teixeira M, Sterkers O, Ferrary E

机构信息

Institut National de la Santé et de la Recherche Médicale U251, Department of Physiology, Faculté Xavier Bichat, Université Paris 7, France.

出版信息

Hear Res. 1995 Jul;87(1-2):16-20. doi: 10.1016/0378-5955(95)00074-e.

DOI:10.1016/0378-5955(95)00074-e

PMID:8567433

Abstract

The effect of cisplatin on the electrochemical composition of the cochlear endolymph was studied in Long-Evans rats three days after a single intraperitoneal injection (8 mg/kg b.w.). A dose 2/3 of LD50 induced a decrease of the endolymphatic concentration of potassium whereas the endocochlear potential was unaffected. The discrepancy between these two findings indicated that cisplatin did not alter the mechanisms involved in the genesis of the endocochlear potential but modified the passive K transport into endolymph.

摘要

在单次腹腔注射（8毫克/千克体重）三天后，研究顺铂对Long-Evans大鼠耳蜗内淋巴电化学组成的影响。2/3半数致死剂量的顺铂会导致内淋巴中钾浓度降低，而耳蜗内电位不受影响。这两个结果之间的差异表明，顺铂并未改变耳蜗内电位产生所涉及的机制，但改变了钾向内淋巴的被动转运。