Boettcher F A, White D R, Mills J H, Schmiedt B N
Department of Otorhinolaryngology and Communicative Sciences, Medical University of South Carolina Charleston 29425, USA.
Hear Res. 1995 Jul;87(1-2):208-19. doi: 10.1016/0378-5955(95)00091-h.
The auditory brainstem response (ABR) was recorded non-invasively from Mongolian gerbils ranging in age from 6 to 36 months. The ABR was elicited using gaussian tone bursts at octave intervals from 1 to 16 kHz. Responses were bandpass filtered from 30 to 300 Hz (LF-ABR; low-frequency component) and from 300 to 3000 Hz (HF-ABR; high-frequency component). In Experiment A, the thresholds of the two components (HF- and LF-ABR) were compared in 6- and 36-month subjects. The LF-ABR varied more with age than did the HF-ABR, particularly at stimulus frequencies of 2 kHz and above. As shown previously for the HF-ABR, the latencies of the LF-ABR increased as a function of hearing loss in aged gerbils whereas amplitudes of the LF-ABR were reduced in all aged gerbils, regardless of age-related threshold elevation. In Experiment B, tone bursts were presented at rates of 11-91/s to gerbils aged 6, 18, 30, and 36 months. Increased repetition rate resulted in an increase in the latency of both the HF- and LF-ABR, but to the same degree in each age group. Similarly, the interpeak intervals of the HF-ABR increased as a function of repetition rate in all subjects to the same degree. Increased age and increased repetition rate both resulted in significant reductions in ABR amplitudes, but rate did not interact with age. The data suggest that (1) the LF-ABR may be more sensitive to aging than is the HF-ABR and (2) there are no age-related changes in the HF- or LF-ABR which are dependent upon the repetition rate.
从6至36月龄的蒙古沙鼠中，以非侵入性方式记录听觉脑干反应（ABR）。使用1至16 kHz倍频程间隔的高斯短纯音诱发ABR。反应经过带通滤波，低频成分（LF-ABR）为30至300 Hz，高频成分（HF-ABR）为300至3000 Hz。在实验A中，比较了6月龄和36月龄受试者的两个成分（HF-ABR和LF-ABR）的阈值。LF-ABR随年龄变化比HF-ABR更大，尤其是在2 kHz及以上的刺激频率时。如先前针对HF-ABR所示，老年沙鼠中LF-ABR的潜伏期随听力损失而增加，而所有老年沙鼠中LF-ABR的振幅均降低，无论与年龄相关的阈值升高情况如何。在实验B中，以11至91次/秒的速率向6、18、30和36月龄的沙鼠呈现短纯音。重复率增加导致HF-ABR和LF-ABR的潜伏期均增加，但每个年龄组增加的程度相同。同样，所有受试者中HF-ABR的峰间期随重复率增加的程度相同。年龄增加和重复率增加均导致ABR振幅显著降低，但重复率与年龄之间没有相互作用。数据表明：（1）LF-ABR可能比HF-ABR对衰老更敏感；（2）HF-ABR或LF-ABR中不存在依赖于重复率的与年龄相关的变化。
