Department of Speech, Language, and Hearing Sciences, University of Florida , Gainesville , USA.
Int J Audiol. 2014 Mar;53 Suppl 2(0 2):S53-65. doi: 10.3109/14992027.2013.865844.
Prevention of temporary threshold shift (TTS) after laboratory-based exposure to pure-tones, broadband noise, and narrowband noise signals has been achieved, but prevention of TTS under these experimental conditions may not accurately reflect protection against hearing loss following impulse noise. This study used a controlled laboratory-based TTS paradigm that incorporated impulsive stimuli into the exposure protocol; development of this model could provide a novel platform for assessing proposed therapeutics.
Participants played a video game that delivered gunfire-like sound through headphones as part of a target practice game. Effects were measured using audiometric threshold evaluations and distortion product otoacoustic emissions (DPOAEs). The sound level and number of impulses presented were sequentially increased throughout the study.
Participants were normal-hearing students at the University of Florida who provided written informed consent prior to participation.
TTS was not reliably induced by any of the exposure conditions assessed here. However, there was significant individual variability, and a subset of subjects showed TTS under some exposure conditions.
A subset of participants demonstrated reliable threshold shifts under some conditions. Additional experiments are needed to better understand and optimize stimulus parameters that influence TTS after simulated impulse noise.
在基于实验室的纯音、宽带噪声和窄带噪声信号暴露后,已实现了对暂时阈移(TTS)的预防,但在这些实验条件下预防 TTS 可能无法准确反映对脉冲噪声引起的听力损失的保护。本研究使用了一种基于实验室的受控 TTS 范式,该范式将脉冲刺激纳入暴露方案中;该模型的开发可为评估拟议治疗方法提供新的平台。
参与者通过耳机玩了一个类似于枪声的视频游戏,作为靶场练习游戏的一部分。使用听力阈值评估和畸变产物耳声发射(DPOAE)来测量效果。在整个研究过程中,声级和脉冲数逐渐增加。
参与者是佛罗里达大学听力正常的学生,他们在参与前提供了书面知情同意书。
这里评估的任何暴露条件均未可靠地引起 TTS。然而,存在显著的个体差异,并且一部分受试者在某些暴露条件下出现 TTS。
一部分参与者在某些条件下表现出可靠的阈值变化。需要进行更多的实验来更好地理解和优化影响模拟脉冲噪声后 TTS 的刺激参数。