磷酸钙（Ca-P）涂层对松质骨反应的影响：一项组织学研究。

Effect of calcium phosphate (Ca-P) coatings on trabecular bone response: a histological study.

作者信息

Caulier H, van der Waerden J P, Paquay Y C, Wolke J G, Kalk W, Naert I, Jansen J A

机构信息

University of Nijmegen, Department of Oral Function, Laboratory of Biomaterials, Dental School, Nijmegen, The Netherlands.

出版信息

J Biomed Mater Res. 1995 Sep;29(9):1061-9. doi: 10.1002/jbm.820290906.

DOI:10.1002/jbm.820290906

PMID:8567704

Abstract

The trabecular bone response to noncoated and fluorapatite (FA), hydroxyapatite (HA), and hydroxyapatite heat-treated (HAHT) plasma-sprayed coated implants was investigated in a goat animal model. Forty-eight cylindrical implants were inserted into the trabecular bone of the lateral and medial femoral condyles of twelve goats according to a split plot design. After an implantation period of twelve weeks, the bone-implant interface was evaluated histologically. Quantitative histomorphometrical measurements demonstrated a significant difference in bone contact between implants inserted in the lateral and medial condyles. In addition, a significant difference in bone apposition was observed between the coated and the uncoated implants. Finally, all Ca-P coatings showed reduction in coating thickness. Measurements revealed that FA and HAHT showed less reduction in coating thickness than HA coating. Despite the coating reduction, the bone remained in close contact with the implant surface.

摘要

在山羊动物模型中研究了松质骨对未涂层和氟磷灰石（FA）、羟基磷灰石（HA）以及羟基磷灰石热处理（HAHT）等离子喷涂涂层植入物的反应。根据裂区设计，将48个圆柱形植入物植入12只山羊股骨内外侧髁的松质骨中。植入12周后，对骨-植入物界面进行组织学评估。定量组织形态计量学测量表明，植入股骨内外侧髁的植入物之间骨接触存在显著差异。此外，涂层植入物和未涂层植入物之间观察到骨贴附存在显著差异。最后，所有钙磷涂层的涂层厚度均减小。测量结果显示，FA和HAHT的涂层厚度减小程度小于HA涂层。尽管涂层厚度减小，但骨仍与植入物表面紧密接触。