Van Blerkom J, Davis P
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309, USA.
Hum Reprod. 1995 Aug;10(8):2179-82. doi: 10.1093/oxfordjournals.humrep.a136264.
This study examined the feasibility of isolating and transferring the centrosome-containing region of spermatozoa to mature human oocytes. The findings demonstrate that individual sperm centrosomes can be transferred and are capable of nucleating maternal tubulin to form a well-developed sperm aster in the recipient oocyte. The results are discussed with respect to centrosome function in early human development and applications in clinical in-vitro fertilization in the treatment of certain forms of male factor infertility.
本研究探讨了分离精子含中心体区域并将其转移至成熟人类卵母细胞的可行性。研究结果表明，单个精子中心体能够被转移，并且能够使母体微管蛋白成核，从而在受体卵母细胞中形成发育良好的精子星体。本文结合早期人类发育过程中的中心体功能以及在治疗某些形式男性因素不孕症的临床体外受精中的应用对这些结果进行了讨论。
