人类早期发育和不孕症中的父本中心体动力学
Paternal centrosomal dynamics in early human development and infertility.
作者信息
Sathananthan A H
机构信息
La Trobe University, Melbourne, Australia.
出版信息
J Assist Reprod Genet. 1998 Mar;15(3):129-39. doi: 10.1023/a:1023056804548.
PURPOSE
Our purpose was to demonstrate the dynamics of the human sperm centrosome during fertilization and cleavage.
METHODS
Human gametes, fertilized oocytes, and preimplantation embryos were examined by transmission electron microscopy.
RESULTS
The functional sperm centrosome containing a typical centriole (proximal) is inherited at fertilization and forms a sperm monoaster. It then replicates and is perpetuated during cleavage. It organizes the mitotic apparatus at each stage of cleavage up to the hatching blastocyst stage. Bipolar spindles are formed in all monospermic and most dispermic embryos. Occasionally, two sperm asters and tripolar spindles are formed in dispermic embryos. Centrioles are associated with pronuclei and nuclei at interphases when they duplicate and occupy pivotal positions at spindle poles during mitoses. The maternal centrosome is not functional.
CONCLUSIONS
The human embryo shows paternal centrosome inheritance and perpetuation like most other animals. Inheritance of defective centrosomes may lead to abnormal cleavage and contribute to infertility.
目的
我们的目的是展示人类精子中心体在受精和卵裂过程中的动态变化。
方法
通过透射电子显微镜检查人类配子、受精卵和植入前胚胎。
结果
含有典型中心粒（近端）的功能性精子中心体在受精时被遗传，并形成精子单星体。然后它进行复制并在卵裂过程中持续存在。它在卵裂的每个阶段直至孵化囊胚阶段组织有丝分裂装置。在所有单精受精和大多数双精受精胚胎中形成双极纺锤体。偶尔，在双精受精胚胎中会形成两个精子星体和三极纺锤体。中心粒在间期与原核和细胞核相关联，此时它们进行复制，并在有丝分裂期间占据纺锤体极的关键位置。母体中心体无功能。
结论
与大多数其他动物一样，人类胚胎显示父本中心体遗传和延续。有缺陷的中心体遗传可能导致异常卵裂并导致不孕。
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