Fish oil, lipid peroxidation and mammary tumor growth.

There is evidence that the level and especially the type of dietary fat can be an important determinant of mammary tumor development and growth. Diets containing high levels of fish oil have been shown to inhibit or suppress mammary tumor growth. Various mechanisms have been proposed to explain this modulatory activity of dietary fish oil or fats in general on tumor growth; of special interest is lipid peroxidation. The oxidation of long chain polyunsaturated fatty acids present in fish oil, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can produce an array of secondary products of lipid oxidation that may possess a cytostatic or cytolytic capacity.