Jogestrand T, Fehrman-Ekholm I, Angelin B, Berglund L, Gäbel H
Department of Clinical Physiology, Huddinge University Hospital, Sweden.
J Intern Med. 1996 Feb;239(2):177-80.
The initial aim of this study was to evaluate the possibility of influencing atherosclerosis in hyperlipidaemic renal transplant patients by lowering blood lipids with gemfibrozil treatment.
Although this double-blind, randomized trial was stopped after 6 months owing to the suspicion of drug interference, we report here on the results of baseline ultrasonographic examinations.
The outpatient clinic at the Department of Transplantation Surgery, Huddinge University Hospital, Huddinge, Sweden.
The carotid arteries were examined in 16 out of the 19 kidney transplant patients included in the study using an ultrasonographic duplex scanner.
Plaque occurrence and the common carotid intima-media thickness of the renal transplant recipients were compared to the same parameters in a normotensive control group of approximately the same age from a previous study.
An increased prevalence of plaque (75% of the patients having plaque on one or both sides) was seen in the hyperlipidaemic renal transplant patients in comparison with the control group (16%; P < 0.001). The common carotid intima-media complex was thicker (P < 0.05), and the lumen diameter and the calculated cross-sectional intima-media area were greater (P < 0.01-0.001) in the transplant recipients.
Markedly increased atherosclerotic wall changes are seen in the carotid arteries of patients with hyperlipidaemia after renal transplantation.
本研究的初始目的是评估使用吉非贝齐治疗降低血脂对高脂血症肾移植患者动脉粥样硬化的影响可能性。
尽管这项双盲随机试验因怀疑药物干扰在6个月后停止，但我们在此报告基线超声检查结果。
瑞典胡丁厄市胡丁厄大学医院移植外科门诊。
使用超声双功能扫描仪对研究纳入的19例肾移植患者中的16例进行颈动脉检查。
将肾移植受者的斑块发生率和颈总动脉内膜中层厚度与先前研究中年龄相近的正常血压对照组的相同参数进行比较。
与对照组（16%）相比，高脂血症肾移植患者的斑块患病率增加（75%的患者一侧或双侧有斑块；P<0.001）。移植受者的颈总动脉内膜中层复合体更厚（P<0.05），管腔直径和计算得出的内膜中层横截面积更大（P<0.01 - 0.001）。
肾移植后高脂血症患者的颈动脉出现明显增加的动脉粥样硬化壁改变。
