Nafar Mohsen, Khatami Fatemeh, Kardavani Babak, Farjad Reza, Pour-Reza-Gholi Fatemeh, Firouzan Ahmad, Kalantar Akbar, Farhangi Soudabeh, Einollahi Behzad
Urology Nephrology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Exp Clin Transplant. 2009 Mar;7(1):33-9.
We investigated the effects of folic acid supplementation on plasma total homocysteine levels and carotid intima-media thickness after kidney transplant.
Sixty patients who had undergone a kidney transplant were studied in this double-blind, randomized, placebo-controlled clinical trial. Those subjects were randomized to receive either 5 mg/d of oral folic acid or an equivalent dosage of placebo. The main outcome variables were the plasma total homocysteine level and carotid intima-media thickness (determined via B-mode sonography) at baseline and 2, 4, and 6 months after kidney transplant. We used independent and paired sample t tests for data analysis.
The mean age of the patients was 40.9 -/+ 10 years, and 32 of those subjects (58.2%) were men. In the control group, the plasma total homocysteine levels were 19 micromol/L at baseline, 18.7 micromol/L after 2 months, 19.3 micromol/L after 4 months, and 20 micromol/L after 6 months; and the carotid intima-media thickness measurements were 0.81 mm at baseline, 0.82 mm after 2 months, 0.84 mm after 4 months, and 0.85 mm after 6 months. In the folic acid group, the plasma total homocysteine levels were 18.5 micromol/L at baseline, 4.7 micromol/L after 2 months, 12.9 micromol/L after 4 months, and 10.9 micromol/L after 6 months; and the carotid intima-media thickness measurements were 0.73 mm at baseline, 0.73 mm after 2 months, 0.72 mm after 4 months, and 0.71 mm after 6 months.
Folic acid supplementation reduces both the plasma total homocysteine level and carotid intima-media thickness shortly after kidney transplant.
我们研究了补充叶酸对肾移植后血浆总同型半胱氨酸水平和颈动脉内膜中层厚度的影响。
在这项双盲、随机、安慰剂对照临床试验中，对60例接受肾移植的患者进行了研究。这些受试者被随机分为两组，分别接受5毫克/天的口服叶酸或等量的安慰剂。主要观察变量为肾移植前及移植后2、4和6个月时的血浆总同型半胱氨酸水平和颈动脉内膜中层厚度（通过B型超声测定）。我们使用独立样本t检验和配对样本t检验进行数据分析。
患者的平均年龄为40.9±10岁，其中32例（58.2%）为男性。在对照组中，血浆总同型半胱氨酸水平在基线时为19微摩尔/升，2个月后为18.7微摩尔/升，4个月后为19.3微摩尔/升，6个月后为20微摩尔/升；颈动脉内膜中层厚度测量值在基线时为0.81毫米，2个月后为0.82毫米，4个月后为0.84毫米，6个月后为0.85毫米。在叶酸组中，血浆总同型半胱氨酸水平在基线时为18.5微摩尔/升，2个月后为4.7微摩尔/升，4个月后为12.9微摩尔/升，6个月后为10.9微摩尔/升；颈动脉内膜中层厚度测量值在基线时为0.73毫米，2个月后为0.73毫米，4个月后为0.72毫米，6个月后为0.71毫米。
肾移植后短期内补充叶酸可降低血浆总同型半胱氨酸水平和颈动脉内膜中层厚度。
