Perkin E M, Rubtsov M A, Rubtsova N I
Khirurgiia (Mosk). 1995(6):23-5.
Sixty-two patients with exacerbation of duodenal ulcer were tested for Helicobacter pylori (HP). Bacterial invasion was found in 54 out 62 patients (87%). The degree of bacterial dissemination, the physiological resistance of the tegmental epithelium, and granulocytic infiltration of the mucosa were studied one and three months after selective proximal vagotomy (SPV) in 16 patients with HP. The control group consisted of seven patients without HP. It was found that bacterial invasion led to diminution of the physiological resistance of the tegmental epithelium and caused a chronic inflammatory process in the mucosal stroma. Bacterial dissemination after the operation not only corresponded to its initial level in the duodenum but tended to increase in the antrum and fundus of the stomach.
对62例十二指肠溃疡恶化患者进行了幽门螺杆菌（HP）检测。62例患者中有54例（87%）发现细菌侵入。对16例感染HP的患者在选择性近端迷走神经切断术（SPV）后1个月和3个月研究了细菌扩散程度、被覆上皮的生理抵抗力以及黏膜的粒细胞浸润情况。对照组由7例未感染HP的患者组成。结果发现，细菌侵入导致被覆上皮的生理抵抗力降低，并在黏膜基质中引发慢性炎症过程。术后细菌扩散不仅与十二指肠中的初始水平相当，而且在胃窦和胃底有增加的趋势。
