Riggs J E
Department of Neurology, Medicine, and Community Medicine, West Virginia University Health Sciences Center, Morgantown 26506-9180, USA.
Mech Ageing Dev. 1995 Jul 14;81(2-3):131-8. doi: 10.1016/0047-6374(95)01582-k.
Multiple myeloma mortality rates in the elderly are increasing. Using published United States mortality data, annual age-specific multiple myeloma mortality rates from 1968 to 1989 were determined for age groups over age 60 and compared to corresponding annual age group population sizes. Rising multiple myeloma mortality rates among the elderly in the United States from 1968 to 1989 were increasingly dependent, with increasing age, upon increasing age group population size. This finding suggests that differential survival, and its effect upon the surviving gene pool in an aging population, may account for observed increasing multiple myeloma mortality rates in recent successive elderly cohorts. A similar conclusion regarding increasing multiple myeloma mortality rates in the elderly has been derived using the Strehler-Mildvan modification of the Gompertz relationship.
老年人多发性骨髓瘤的死亡率正在上升。利用已公布的美国死亡率数据，确定了1968年至1989年60岁以上各年龄组的特定年龄年度多发性骨髓瘤死亡率，并与相应年龄组的年度人口规模进行了比较。1968年至1989年期间，美国老年人多发性骨髓瘤死亡率的上升越来越依赖于年龄组人口规模的增加，且年龄越大依赖程度越高。这一发现表明，不同的生存率及其对老龄化人口中存活基因库的影响，可能是近期连续老年人群体中观察到的多发性骨髓瘤死亡率上升的原因。使用Gompertz关系的Strehler-Mildvan修正法也得出了关于老年人多发性骨髓瘤死亡率上升的类似结论。
