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磷脂酶抑制剂奎纳克林对沙土鼠海马缺血/再灌注损伤的脑保护作用

Cerebroprotective action of the phospholipase inhibitor quinacrine in the ischemia/reperfused gerbil hippocampus.

作者信息

Phillis J W

机构信息

Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA.

出版信息

Life Sci. 1996;58(6):PL97-101. doi: 10.1016/0024-3205(95)02320-8.

DOI:10.1016/0024-3205(95)02320-8
PMID:8569417
Abstract

The phospholipase inhibitor quinacrine (mepacrine; 5 mg/kg, i.p.) was tested for cerebroprotective activity in a gerbil stroke model. Quinacrine significantly reduced stroke injury assessed by locomotor activity monitoring and by histopathological measurement of hippocampal CA1 pyramidal cell loss. It is proposed that phospholipase activation, resulting from elevated levels of intracellular calcium, may contribute to ischemia-evoked neuronal injury.

摘要

在沙鼠中风模型中对磷脂酶抑制剂喹吖因（米帕林；5毫克/千克，腹腔注射）的脑保护活性进行了测试。通过运动活动监测以及海马CA1锥体细胞损失的组织病理学测量评估，喹吖因显著减轻了中风损伤。有人提出，细胞内钙水平升高导致的磷脂酶激活可能会导致缺血诱发的神经元损伤。

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