Durica S, Zakula Z, Isenović E, Ratković M, Ribarac-Stepić N
Clinical Hospital Center Zvezdara, Beograd, Yugoslavia.
Med Pregl. 1993;46 Suppl 1:82-4.
TSH receptors were analyzed by equilibrium binding method of Scatchard in nodular and perinodular specimens surgically obtained from nine patients suffering from thyroid nodular goiter, which were clinically euthyroid. Among these patients, the group of those at "real risk" for reappearance of postoperative thyroid nodule in follow-up period was formed. The obtained results showed that there were no significant differences in specific 125I-bTSH binding between perinodular (assumed to be normal by PH analysis) and nodular tissues. The level of high affinity receptors was higher in perinodular than nodular specimens, while low affinity binding sites were increased in nodular tissue. Decreased level of high affinity and increased content of low affinity binding sites were observed in perinodular compared to nodular specimens obtained from patients of "real risk" group. These results give evidences for real risk of postoperative compensatory hypertrophy and thyroid goiter relapse in follow-up during long-term period.
采用Scatchard平衡结合法对9例临床甲状腺功能正常的甲状腺结节性甲状腺肿患者手术切除的结节及结节周围组织中的促甲状腺激素（TSH）受体进行分析。在这些患者中，形成了随访期有术后甲状腺结节复发“真正风险”的患者组。所得结果显示，结节周围组织（经病理分析假定为正常）与结节组织之间的特异性125I-bTSH结合无显著差异。结节周围组织中高亲和力受体水平高于结节组织，而结节组织中低亲和力结合位点增加。与“真正风险”组患者的结节标本相比，结节周围组织中高亲和力水平降低，低亲和力结合位点含量增加。这些结果为长期随访期间术后代偿性肥大和甲状腺肿复发的真正风险提供了证据。
