Oggiano N, Kantar A, Bruni S, Cutrona F M, Fabbrizi E, Piccinini R, De Cristofaro L, Lanfranchi E, Giorgi P L
Clinica Pediatrica, Università degli Studi, Ancona.
Minerva Pediatr. 1995 Oct;47(10):427-31.
Changes in time course of blood partial pressures of oxygen (PtcO2) and carbon dioxide (PtcCO2) before, during and after challenge with ultrasonically nebulized distilled water (UNDW) were evaluated in 22 children with mild asthma in basal conditions, and after 8 weeks of therapy with inhaled nedocromil sodium at a daily dosage of 8 or 16 mg. PtcO2 and PtcCO2 were followed using transcutaneous O2 and CO2 monitoring system. All asthmatic subjects presented a significant decrease in PtcO2 and/or PtcCO2 (> 20% basal value) during or after challenge. After therapy, the decrease in PtcO2 and PtcCO2 was normalized in the group treated with 16 mg/day, whereas only a partial yet significant reduction in the decrease of O2 and CO2 was observed in the group assuming 8 mg/-day. These data indicate that inhaled nedocromil is effective in treating bronchial hyperresponsiveness in childhood and that the dose required to achieve this effect is of 16 mg/day.
在基础状态下以及每日吸入8毫克或16毫克奈多罗米钠治疗8周后，对22例轻度哮喘儿童在超声雾化蒸馏水（UNDW）激发前、激发期间和激发后的氧分压（PtcO2）和二氧化碳分压（PtcCO2）的时间进程变化进行了评估。使用经皮氧和二氧化碳监测系统跟踪PtcO2和PtcCO2。所有哮喘受试者在激发期间或激发后PtcO2和/或PtcCO2均显著降低（>基础值的20%）。治疗后，16毫克/天治疗组的PtcO2和PtcCO2降低情况恢复正常，而8毫克/天治疗组仅观察到氧和二氧化碳降低的部分但显著减少。这些数据表明，吸入奈多罗米对治疗儿童支气管高反应性有效，达到此效果所需的剂量为16毫克/天。
