Iqbal Z
Department of Neurology, School of Medicine, Northwestern University, Chicago, Illinois, USA.
Mol Cell Biochem. 1995 Aug-Sep;149-150:233-40. doi: 10.1007/BF01076582.
The excitatory amino acids (EAA), L-glutamate and L-aspartate were initially advanced as excitatory neurotransmitters some 30 years ago but in the past few years investigations on EAA have proceeded rapidly from the identification of the putative neurotransmitters and characterization of their receptors to the clarification of their role in development, learning, memory, and neuropathology. The NMDA(N-methyl-D-aspartate) class of glutamate receptor has been the subject of much recent interdisciplinary study, as NMDA receptors render over stimulated neurons susceptible to injury and death. This review is focused on the involvement of polyamines in EAA receptor-mediated neuronal signal transduction mechanisms.
大约30年前，兴奋性氨基酸（EAA），即L-谷氨酸和L-天冬氨酸，最初被认为是兴奋性神经递质，但在过去几年中，对EAA的研究迅速从假定神经递质的鉴定及其受体的表征发展到阐明它们在发育、学习、记忆和神经病理学中的作用。谷氨酸受体的NMDA（N-甲基-D-天冬氨酸）类一直是近期许多跨学科研究的主题，因为NMDA受体使过度刺激的神经元易受损伤和死亡。这篇综述聚焦于多胺在EAA受体介导的神经元信号转导机制中的作用。
