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申克孢子丝菌所致的致命性真菌血症。

Fatal fungaemia due to Sporothrix schenckii.

作者信息

Castrejón O V, Robles M, Zubieta Arroyo O E

机构信息

Instituto Nacional de Diagnóstico y Referencia Epidemiológica INDRE, Departamento de Parasitología, Col. Sto. Thomás, Mexico, D.F.

出版信息

Mycoses. 1995 Sep-Oct;38(9-10):373-6. doi: 10.1111/j.1439-0507.1995.tb00067.x.

DOI:10.1111/j.1439-0507.1995.tb00067.x
PMID:8569812
Abstract

A clinical case is reported of a 78-year-old male with antecedents of diabetes and alcoholism who was hospitalized because he showed cutaneous lesions on the face and extremities suggesting cutaneous tuberculosis, but after a first histological study cutaneous leishmaniasis was erroneously diagnosed. Because of some unusual characteristics of the patient, the skin biopsies were carefully re-examined, as well as blood smears, which revealed elongated yeast form-like cells suggestive of Sporothrix schenckii. The diagnosis was confirmed when the fungus grew in mice and in Sabouraud cultures inoculated with blood samples from the patient. It is recommended that Sp. schenckii is included in the differential diagnosis of ulcerative cutaneous lesions in patients from Mexican humid areas.

摘要

报告了一例临床病例,患者为一名78岁男性,有糖尿病和酗酒史,因面部和四肢出现提示皮肤结核的皮肤病变而住院,但在首次组织学研究后被错误诊断为皮肤利什曼病。由于患者有一些不寻常的特征,对皮肤活检以及血涂片进行了仔细复查,发现了类似酵母样的细长细胞,提示申克孢子丝菌。当从患者血液样本接种的小鼠和沙保弱培养基中培养出真菌时,诊断得到证实。建议将申克孢子丝菌纳入墨西哥潮湿地区溃疡性皮肤病变患者的鉴别诊断中。

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引用本文的文献

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Sporotrichosis: a Comprehensive Review on Recent Drug-Based Therapeutics and Management.孢子丝菌病:近期基于药物的治疗与管理综合综述
Curr Dermatol Rep. 2022;11(2):110-119. doi: 10.1007/s13671-022-00358-5. Epub 2022 Mar 17.
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Sporotrichosis In Immunocompromised Hosts.
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J Fungi (Basel). 2019 Jan 11;5(1):8. doi: 10.3390/jof5010008.
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Cutaneous Disseminated and Extracutaneous Sporotrichosis: Current Status of a Complex Disease.皮肤播散性和皮肤外孢子丝菌病:一种复杂疾病的现状
J Fungi (Basel). 2017 Feb 10;3(1):6. doi: 10.3390/jof3010006.
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In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods.采用三种不同方法测定申克孢子丝菌对六种抗真菌药物的体外敏感性。
Antimicrob Agents Chemother. 2007 Jul;51(7):2420-3. doi: 10.1128/AAC.01176-06. Epub 2007 Apr 16.
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Involvement of fungal cell wall components in adhesion of Sporothrix schenckii to human fibronectin.申克孢子丝菌的真菌细胞壁成分在其与人纤连蛋白黏附中的作用。
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