Wildhagen M F, Christiaens G C, Habbema J D
Erasmus Universiteit, instituut Maatschappelijke Gezondheidszorg, Rotterdam.
Ned Tijdschr Geneeskd. 1996 Jan 13;140(2):85-9.
To check whether serum screening for Down syndrome and open neural tube defects satisfies the criteria set by the 'Committee Genetic screening' of the Dutch Health Council.
Theoretical evaluation.
Serum screening (the combined serum assessment of alpha-fetoprotein, human chorionic gonadotrophin and unconjugated oestriol, taking into consideration maternal age) was assessed against the Dutch Health Council criteria. The absolute criteria could be subdivided into a group of general conditions not related to a particular screening programme, and a group of programme-specific conditions.
Population serum screening satisfied some of the absolute criteria, while the programme-specific conditions should be realised in an actual screening programme. Psychological and community consequences of such a screening have not yet been investigated in the Dutch population.
检查唐氏综合征和开放性神经管缺陷的血清筛查是否符合荷兰卫生委员会“遗传筛查委员会”设定的标准。
理论评估。
根据荷兰卫生委员会的标准，对血清筛查（结合甲胎蛋白、人绒毛膜促性腺激素和未结合雌三醇的血清综合评估，并考虑孕妇年龄）进行评估。绝对标准可细分为一组与特定筛查项目无关的一般条件，以及一组特定项目条件。
人群血清筛查满足部分绝对标准，而特定项目条件应在实际筛查项目中实现。此类筛查对荷兰人群的心理和社区影响尚未进行研究。
