发热和寒战作为硫唑嘌呤超敏反应的唯一症状。

Fever and rigors as sole symptoms of azathioprine hypersensitivity.

作者信息

Smak Gregoor P J, van Saase J L, Weimar W, Kramer P

机构信息

Department of Internal Medicine and Nephrology, St. Clara Hospital, Rotterdam, Netherlands.

出版信息

Neth J Med. 1995 Dec;47(6):288-90. doi: 10.1016/0300-2977(95)00047-x.

DOI:10.1016/0300-2977(95)00047-x

PMID:8569935

Abstract

The case history of a haemodialysis patient with fever and rigors is presented. This diagnostic problem turned out to be a hypersensitivity reaction to azathioprine, with identical complaints recurring after a rechallenge with azathioprine, findings which resolved on discontinuation of this drug. The more extended indications for use of azathioprine warrant attention to the possibility of side-effects like drug fever.

摘要

本文介绍了一名血液透析患者出现发热和寒战的病例史。这个诊断问题原来是对硫唑嘌呤的超敏反应，再次使用硫唑嘌呤后出现了相同的症状，停用该药物后症状缓解。硫唑嘌呤使用指征的进一步扩大，需要关注药物热等副作用的可能性。