Saway P A, Heck L W, Bonner J R, Kirklin J K
Department of Medicine and Cardiovascular Surgery, University of Alabama at Birmingham Hospitals 35294.
Am J Med. 1988 May;84(5):960-4. doi: 10.1016/0002-9343(88)90079-4.
Fever in a transplant recipient is an important sign of graft rejection or infection. Rarely, fever may result from an immunosuppressive agent used to prevent graft rejection. A case of fever, rigors, arthralgias, and myalgias is reported in a cardiac transplant recipient in whom azathioprine therapy was recently begun. These findings resolved on discontinuation of the azathioprine, recurred on rechallenge, and were most consistent with a hypersensitivity reaction. The clinical spectrum of reported azathioprine hypersensitivity reactions is reviewed.
移植受者发热是移植排斥或感染的重要体征。很少情况下，发热可能由用于预防移植排斥的免疫抑制剂引起。本文报告了一例心脏移植受者，该患者近期开始使用硫唑嘌呤治疗，出现发热、寒战、关节痛和肌痛。停用硫唑嘌呤后这些症状消失，再次用药时复发，最符合超敏反应。本文对已报道的硫唑嘌呤超敏反应的临床谱进行了综述。
