脊椎动物视网膜中的细胞命运决定

Cepko C L, Austin C P, Yang X, Alexiades M, Ezzeddine D

Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.

Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):589-95. doi: 10.1073/pnas.93.2.589.

In the vertebrate central nervous system, the retina has been a useful model for studies of cell fate determination. Recent results from studies conducted in vitro and in vivo suggest a model of retinal development in which both the progenitor cells and the environment change over time. The model is based upon the notion that the mitotic cells within the retina change in their response properties, or "competence", during development. These changes presage the ordered appearance of distinct cell types during development and appear to be necessary for the production of the distinct cell types. As the response properties of the cells change, so too do the environmental signals that the cells encounter. Together, intrinsic properties and extrinsic cues direct the choice of cell fate.

在脊椎动物的中枢神经系统中，视网膜一直是研究细胞命运决定的有用模型。近期体外和体内研究结果提示了一种视网膜发育模型，其中祖细胞和环境都会随时间发生变化。该模型基于这样一种观念，即视网膜内的有丝分裂细胞在发育过程中其反应特性或“能力”会发生变化。这些变化预示着发育过程中不同细胞类型的有序出现，并且似乎是产生不同细胞类型所必需的。随着细胞反应特性的变化，细胞所遇到的环境信号也会发生变化。内在特性和外在线索共同引导细胞命运的选择。