Cepko C L
Department of Genetics Howard Hughes Medical Institute Harvard Medical School 200 Longwood Avenue Boston Massachusetts 02115 USA.
Curr Opin Neurobiol. 1999 Feb;9(1):37-46. doi: 10.1016/s0959-4388(99)80005-1.
A fundamental issue concerning development of the vertebrate retina is the relative contributions of extrinsic and intrinsic cues to the determination of cell fate. Recent findings suggest that retinal progenitors go through a series of changes in intrinsic properties that control their competence to make different cell types and that extrinsic cues influence the ratios of the cell types that they produce. Recent studies of the role of the basic helix-loop-helix genes in retinal development have indicated that they can regulate competence and/or other aspects of cell fate determination.
脊椎动物视网膜发育的一个基本问题是外在和内在信号对细胞命运决定的相对贡献。最近的研究结果表明，视网膜祖细胞经历了一系列内在特性的变化，这些变化控制着它们产生不同细胞类型的能力，并且外在信号会影响它们所产生的细胞类型的比例。最近关于碱性螺旋-环-螺旋基因在视网膜发育中的作用的研究表明，它们可以调节细胞命运决定的能力和/或其他方面。
