Haxby J V, Ungerleider L G, Horwitz B, Maisog J M, Rapoport S I, Grady C L
Section on Functional Brain Imaging, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.
Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):922-7. doi: 10.1073/pnas.93.2.922.
A dissociation between human neural systems that participate in the encoding and later recognition of new memories for faces was demonstrated by measuring memory task-related changes in regional cerebral blood flow with positron emission tomography. There was almost no overlap between the brain structures associated with these memory functions. A region in the right hippocampus and adjacent cortex was activated during memory encoding but not during recognition. The most striking finding in neocortex was the lateralization of prefrontal participation. Encoding activated left prefrontal cortex, whereas recognition activated right prefrontal cortex. These results indicate that the hippocampus and adjacent cortex participate in memory function primarily at the time of new memory encoding. Moreover, face recognition is not mediated simply by recapitulation of operations performed at the time of encoding but, rather, involves anatomically dissociable operations.
通过正电子发射断层扫描测量与记忆任务相关的局部脑血流量变化，证明了参与面部新记忆编码及后续识别的人类神经系统之间存在分离。与这些记忆功能相关的脑结构几乎没有重叠。右侧海马体及相邻皮质中的一个区域在记忆编码期间被激活，但在识别期间未被激活。新皮质中最显著的发现是前额叶参与的侧化。编码激活了左前额叶皮质，而识别激活了右前额叶皮质。这些结果表明，海马体及相邻皮质主要在新记忆编码时参与记忆功能。此外，面部识别并非简单地通过重复编码时执行的操作来介导，而是涉及解剖学上可分离的操作。
