Meunier M, Bachevalier J, Mishkin M, Murray E A
Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892.
J Neurosci. 1993 Dec;13(12):5418-32. doi: 10.1523/JNEUROSCI.13-12-05418.1993.
Performance on visual delayed nonmatching-to-sample was assessed in rhesus monkeys with combined and separate ablations of the perirhinal and entorhinal cortex, as well as in unoperated controls. Combined (i.e., rhinal cortex) lesions yielded a striking impairment on this task, one almost as severe as that seen after combined amygdalohippocampal removals that included some of this subjacent cortex (Mishkin, 1978; Murray and Mishkin, 1984). Ablations of the perirhinal cortex alone produced a deficit nearly as severe as that found after rhinal cortex lesions, whereas ablations of the entorhinal cortex alone produced only a mild deficit. Contrary to the conclusion from an earlier study (Murray and Mishkin, 1986), the present results demonstrate not only that damage limited to the rhinal cortex is sufficient to produce a severe loss in visual recognition, but also that such damage leads to a far greater loss than damage to any other single structure in the medial part of the temporal lobe.
在恒河猴身上，通过联合切除和分别切除鼻周皮质与内嗅皮质，以及在未手术的对照组中，评估了视觉延迟非匹配样本任务的表现。联合（即鼻周皮质）损伤在这项任务上产生了显著的损害，几乎与包括部分相邻皮质的杏仁核 - 海马联合切除术后所见的损害一样严重（米什金，1978年；默里和米什金，1984年）。单独切除鼻周皮质产生的缺陷几乎与鼻周皮质损伤后发现的缺陷一样严重，而单独切除内嗅皮质仅产生轻微缺陷。与早期一项研究（默里和米什金，1986年）的结论相反，目前的结果不仅表明局限于鼻周皮质的损伤足以导致视觉识别能力的严重丧失，而且还表明这种损伤导致的损失远比颞叶内侧任何其他单一结构的损伤所导致的损失大得多。
