Gerra G, Fertonani G, Tagliavini P, Zaimovic A, Delsignore R, Maestri D, Avanzini P, Caccavari R, Brambilla F
Centro Studi Farmacotossicodipendenze, SERT, Parma, Italy.
Psychiatry Res. 1995 Sep 29;58(2):153-60. doi: 10.1016/0165-1781(95)02665-j.
The function of the central serotonergic system was examined indirectly through the measurement of prolactin (PRL) and cortisol responses to fenfluramine challenges in 27 heroin addicts 2 months after detoxification and in nine healthy volunteers. Heroin abusers included nine addicts with comorbid depressive disorders (Group A), nine with aggressive behavior and antisocial personality (Group B), and nine with heroin addiction uncomplicated by other Axis I and II psychiatric disorders (Group C). PRL and cortisol responses of patients in Group A were blunted, while those of patients in Groups B and C did not differ from those of the healthy volunteers. Cortisol responses in Group A differed significantly from those in the other patient groups and in the normal comparison group for AUC analyses, but the diagnosis x time interaction showed a significant difference only between Group A and the normal group. Our data suggest that the function of the serotonergic system is impaired in heroin addicts with comorbid depression but not in heroin addicts who are not clinically depressed. Thus, the serotonergic system does not appear to be impaired by prolonged opioid exposure, per se.
通过测量27名戒毒2个月后的海洛因成瘾者及9名健康志愿者对芬氟拉明激发试验的催乳素（PRL）和皮质醇反应，间接研究了中枢5-羟色胺能系统的功能。海洛因滥用者包括9名合并抑郁障碍的成瘾者（A组）、9名有攻击行为和反社会人格的成瘾者（B组）以及9名无其他轴I和轴II精神障碍的单纯海洛因成瘾者（C组）。A组患者的PRL和皮质醇反应减弱，而B组和C组患者的反应与健康志愿者无异。在AUC分析中，A组的皮质醇反应与其他患者组及正常对照组有显著差异，但诊断×时间交互作用仅在A组与正常组之间显示出显著差异。我们的数据表明，合并抑郁症的海洛因成瘾者中5-羟色胺能系统功能受损，而无临床抑郁的海洛因成瘾者中该系统功能未受损。因此，5-羟色胺能系统似乎不会因长期接触阿片类物质本身而受损。
