Bohdanecká M, Chadimova M, Reitschlägerová V, Kunes J
Metabolické pracovistĕ a, Institutu klinické a experimentální medicíny, Praha.
Sb Lek. 1994;95(1):25-30.
The effect of temporary and complete renal artery clamping on the plasma concentrations of creatinine (Pcr) and morphologic alterations was studied in the remaining kidney of unilaterally nephrectomized rats. It was demonstrated that 20-minute ischaemia did not entail a significant increase in Pcr although histologic changes were already detectable in the kidney. Thirty-minute ischaemia was associated with appreciable histologic changes in the kidney even though the rise in Pcr was mild and transient. Forty-five and sixty-minute ischaemia was found to be associated with severe histologic changes and a distinct increase in Pcr. Seen from the perspective of transplantation requiring evaluation of the functional status of cadaverous donors, the experimental findings show that normal levels of Pcr do not exclude the possible presence of morphologic changes, and that even major histologic change may manifest themselves in an insignificant increase in Pcr.
在单侧肾切除大鼠的剩余肾脏中，研究了暂时性和完全性肾动脉夹闭对血浆肌酐浓度（Pcr）及形态学改变的影响。结果表明，20分钟的缺血虽然肾脏中已可检测到组织学变化，但并未导致Pcr显著升高。30分钟的缺血与肾脏明显的组织学变化相关，尽管Pcr升高轻微且短暂。45分钟和60分钟的缺血则与严重的组织学变化及Pcr显著升高相关。从需要评估尸体供体功能状态的移植角度来看，实验结果表明，Pcr正常水平并不排除可能存在的形态学变化，而且即使是主要的组织学变化，Pcr的升高也可能不明显。
